Concept
reproductive endocrinology
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GynecologyIntegrative Physiology
Children
Adrenal DiseaseAdrenal HealthAromataseBone HealthCardiovascular Endocrinology
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Institutions
Hypothalamic-Pituitary-Gonadal Axis
1922 - 1947
The period 1922–1947 was dominated by the view that female reproductive physiology is governed by gonadal hormones acting as internal secretions to regulate estrous cycles, ovulation, and maturation across mammals, with cross-species comparisons anchoring early hormone research. A reciprocal hypothalamic-pituitary-gonadal axis with feedback control and sex-hormone antagonism emerged as the central framework that shapes endocrine output, while puberty and developmental endocrinology explored induction of sexually mature conditions via ovarian follicular hormones and tissue-level maturation. Male endocrinology highlighted testicular hormones and androgenic influences on somatic and psychical traits, alongside the maintenance of male glands and androsterone; pregnancy endocrinology tied corpus luteum function to gestation and menstrual regulation, linking ovarian hormones to reproductive timing.
• Female reproductive physiology is framed as governed by gonadal hormones acting as internal secretions that regulate estrous cycles, ovulation, and maturation across mammals. [1] [3] [10] [9] [13] [8] [20]
• Gonads and the pituitary/hypothalamus form a reciprocal endocrine axis, with evidence for feedback control and sex-hormone antagonism shaping endocrine output. [2] [11] [9] [13]
• Developmental endocrinology and puberty involve inducing sexually mature conditions in immature females via ovarian follicular hormones; subsequent hormonal maturation is studied at tissue level. [16] [9] [5] [20]
• Male reproductive endocrinology emphasizes testicular hormones, sperm vitality, and androgenic influences on somatic/psychical traits, alongside maintenance of male glands and androsterone. [7] [4] [19] [17]
• Pregnancy-related endocrinology covers corpus luteum function, urinary excretion products, and ovarian changes during pregnancy, tying ovarian hormones to gestation and menstrual regulation. [18] [15] [12]
Assay-Driven Reproductive Endocrinology
1948 - 1954
Hypothalamic Pituitary Gonadal Axis
1955 - 1964
Reproductive Endocrine Axis
1965 - 1971
Pulsatile Gonadotropin Regulation
1972 - 1978
Gonadotropin-Releasing Hormone Pulsatility
1979 - 1997
Integrated Neuroendocrine Reproduction
1998 - 2004
Kisspeptin-Driven Reproductive Neuroendocrinology
2005 - 2011
Integrated Reproductive Endocrinology
2012 - 2023